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For cardiovascular research context, semaglutide remains the better-evidenced compound by a wide margin
A peer-reviewed study published in JMIR Formative Research in 2025 found that active subscribers on Second Natures GLP-1-supported programme lost an average of 19.1% of their body weight at 12 months, with 77.7% achieving at least 10% weight loss
Seven additional Phase 3 readouts are expected through the remainder of the year, covering applications in type 2 diabetes, obstructive sleep apnea, chronic low back pain, cardiovascular outcomes, and metabolic liver disease
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